I had 3 Reclast infusions over 4.5 years; the last was June 2023. The first infusion had flu-like symptoms for 5 days, brain fog, fatigue, joint aches, irregular heartbeat, and mild nausea. They tailed off quickly after that. The following two infusions had similar but far milder reactions. I have a few autoimmune diseases so am used to reacting to new drugs (even NSAIDs). The infusions did morph my osteoporosis into osteopenia (I'm 70 and do a lot of resistance/weights as well). If your symptoms continue, it would be good to connect with your doctor. https://www.ccjm.org/content/85/9/675 https://pmc.ncbi.nlm.nih.gov/articles/PMC10404464/

So its been approximately 4 moths since my Reclast infusion, and I continue to have issues from it. I had a very negative situation, and I realize everyone’s situation is different, people react differently, but, I have had what I call fallout from it. I was extremely sick for 5 days, and doctors think I may have had an allergic reaction. I am experiencing bone pain in feet, ankles, legs, knees, hips, joints. I notice issues relating to pain in teeth, jaws, and am so worried that maybe it could cause or is causing teeth issues now. I know I personally would not take the infusion again, But I realize that talking with many people, listening to the stories, will help me on the path to what I try next. All these stories and experiences has been so valuable and Im so thankful.

I had Reclast infusion Nov 12th, went thru flu like symptoms for 3 days, end of day 3 started with worst bone and joint pain ever. I was ready to go to the ER. Called clinic and was told to take Claritin along with ibuprofen and Tylenol. I took it for a month and started feeling better. So stopped to test if I still needed it. So far I've been good. Just normal arthritis pain I've always had. I told my NP that I won't be taking it again. I have a year, but next time it'll be something different for sure.

My reclast infusion was late January of 2024. About 10 hours after, I had the severe reaction (rib, back pain, dizziness, temp) some have experienced which lasted just a day or so then subsided. About 2-3 months later, I began having deep pain in my leg-hip to foot which varied in intensity for about 3 months before also subsiding in July. I feel like these are flare ups or waves of something going on as another flare up began late November and is just beginning to subside. The pain is worse at night and when standing from a sitting position. Walking helps and I am trying to balance rest with exercise. I have already told my Dr. I won't take the infusion again when due this month. She acknowledges that about 40% of people have musculoskeletal pain. I will follow to see how others manage this. Hope you feel better soon.

I have an endo appt this week. I am finishing up 18 months of tymlos. I know my doc will be discussing another medication. After reading up on Prolia and Reclast I am scared of these medications. Anyone here have experience with Fosomax?

For about 3 months after my first Reclast infusions, I had intermittent pains moving through different parts of my body. One shoulder locked up on me, I wasn't able to turn my head for a few days, there was pretty intense pain in my right calf muscle. After about 3 months this ' floating' pain disappeared. I had the other 2 infusions the following 2 years with no side effects at all. With bone density testing afterwards, there was quite a notable strengthening of both my right hip and spine. It is a big decision getting infusions and also continuing with the whole course. I hope that your discomfort subsides and that your final outcome is as positive as mine.

Hello @predni, I combined your discussion with an existing discussion titled:

"bone pain four months after Reclast Infusion"
- https://connect.mayoclinic.org/discussion/bone-pain-for-months-after-reclast-infusion/

Here you can meet other members discussion bone pain. @predni, have you had a chance to talk with your provider about the bone pain? Was this a potential side-effect that was discussed prior to treatment?

Hopefully my first and last infusion; been 7 months and the pain is still strong. Continue to have many sluggish days, both shoulders, right more than left awful pain, and left foot, all worse at night! I do not think I have slept a full night since having the infusion. Dr wants to do another infusion in June and recommend I go to Rheumatology because Reclast doesn’t have these side effects, well, yes it does! One thing that seems to stand out, stay very hydrated , might help. I have complications that prevent me from consuming large amounts of fluid and that might be some of my problem! Not sure how long this aches and pain is here for but it has already over stayed it welcome!