Agree . . . 2000 mg a day for 20 years?

I have read that HU can lose its efficacy with prolonged use, so maybe your oncologist has been increasing your dosage over time?

But to me it seems a better strategy would be considering alternative treatments for your ET.

As Eileen says, find an MPN specialist for a second opinion.

Do you have a good dermatologist keeping a close eye on your skin? Many lesions can be fairly easily removed, if caught at an early stage.

Let this be a reminder to all of us. HU makes us more vulnerable to skin cancer. Use a mineral-based sun cream, wear a sun hat, cover as much of your skin as possible when you have to be in the sun.

bchampagne, let us know how it goes.