@debbie75 Mayo prescribed a course of Cymbalta and Naltrexone for a period of time. My supplements were recommended by another medical professional and endorsed by Mayo. I have found that most Doctors are agnostic on supplements. My supplements are B Complex, Magnesium L Threonate, CoQ10, Vitamin C, D-Ribose, Nattokinase, and a multivitamin. I still suffer from LC and for me moderation is key. If I moderate I feel a bit better some days than others. By no means am I cured of LC so are the supplements really helping? I honestly can't answer that without completely stopping to see if there's a change to the worse. I have moved on to Dr. Bruce Patterson's program in hopes of a solution there.