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MGUS and quite high Free Kappa Light Chain and Kappa Lambda Ratio

Blood Cancers & Disorders | Last Active: 5 days ago | Replies (212)
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@rebeccaakabeck

Hi. I'm new here.. I have iga lambda mgus. That's according to the m spike. But my kappa has been the one elevated for over a year? The ratio is normal.. I also have flagged high abs basophils and a b12 deficiency for one a year
Does anyone else have these findings?

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Replies to "Hi. I'm new here.. I have iga lambda mgus. That's according to the m spike. But..."
kayabbott | @kayabbott | 5 days ago

I have IgA kappa MGUS (8 years); kappa is almost 300 and kappa/lambda ratio is 29. My M spike is just above detection. My basophils and other "phils" are on the low side. Elevated basophils and low B12 can be from various causes such as diet (B12), inflammation, infection... I imagine your doctor has you on B12 vitamins/injection now. Consider keeping a food log to see if you are deficient in any food groups, and if any cause symptoms (bloating, tired, brain fog, etc). It would be good for the doctor(s) to determine why your basophils are elevated and B12 is low. Is it correlated to MGUS, gastroenterology, or other problem. https://my.clevelandclinic.org/health/diseases/22099-basophilia

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