I’m 56 and have been on twice-weekly 0.075 mg/day estradiol patches for a few years, entirely for my mental health! I have a Mirena IUD for the progestin portion. I don’t know what constitutes low-dose, and I suspect mine may be on the moderate or possibly even higher side, but it’s the amount that leveled out my horrible perimenopausal depression, so that’s how it was determined. I’ll eventually need to get off of it, but I'm only 5 years in, and I think it can be safe to be on it for around 10 years? Depends on so many things, I suppose.

It was prescribed by a doctor at Mayo. And by the way, I just had open heart surgery in Mayo, a septal myectomy, and I’m still kicking! They didn’t change anything with my estrogen patches while I was in the hospital.

I can’t recommend HRT highly enough, but I was literally losing my life due to depression before I got on it, so I’m probably not your best example from the osteoporosis angle.

Good luck!