Welcome to Connect @redrider48 I’ve heard from others that fatigue is often a side effect from the Hydroxyurea. A number of members have mentioned taking the medication at night and that seems to help with avoiding daytime tiredness.
Here a link to one of the discussions about HU that might be helpful for you.

~What are most common side effects when starting HU (Hydroxyurea)?
https://connect.mayoclinic.org/discussion/hu-side-effects/
What’s your daily dosage?