I'm right there with you but have different medical conditions to juggle.. I have a heart condition(stent placement in 2011), PV diagnosed in 2021 which I am taking 8500 mg of HU per week, intermediate prostate cancer which I have not treated, but am on active surveillance, and somehow without knowing when, suffered a stroke (damage confirmed by a brain scan).. My neurologist said I am an anomaly as I should have experienced symptoms) A minor addition is I have osteonecrosis of my left knee.. Despite this, I exercise every day.. I ride my bike (weather permitting), and swim laps at a health club every day.. All in all I feel very good considering the above.. I often wonder, how long will this last?? I get bloodwork done monthly.. My issue is that I don't want to rock the boat with any additional treatment or medication that could trigger a worsening of any of my conditions.. None of my specialists can really answer the question regarding contraindications of medications or surgery/radiation treatments .. I myself have prioritized my conditions as follows: 1. PV as do NOT want this to morph into leukemia, 2. Avoidance of having another stroke 3. Heart ( currently in great shape) 4. Prostate cancer.. (typically has slow progression).. I guess I am lucky that I currently feel as good as I do and have for the last year.. That allows me to have a positive attitude ...My self analysis is that if my exercise routine becomes more difficult or impossible to continue, I will have to make a treatment decision.. In other words, I am counting on my body to let me know... FYI.. 70 year old male..