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Replies to "I also forgot to mention that I am someone who did much research before choosing this..."
Osteoporosis & Bone Health | Last Active: Dec 23, 2024 | Replies (11)
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Replies to "I also forgot to mention that I am someone who did much research before choosing this..."
What I was trying to say @annar is that you may still be in the "acute phase reaction." I distinguish this from side effects that are longer term. I know that this reaction was common, took many forms, and could go on for 2-3 weeks. Since then I have had no side effects and my second infusion went fine. Just something to consider.
Reclast leaves the system fairly quickly:
"Zoledronic acid has a terminal elimination half-life of 146 hours1. The elimination is triphasic, with an alpha early distribution half-life of 0.23 hours, a beta half-life of 1.75 hours, and terminal elimination half-life of 167 hours2. Zoledronic acid is 39 ± 16% eliminated in the urine as the unmetabolized parent drug1. A complete response, when treating hypercalcemia of malignancy, to a single dose of zoledronic acid is typically seen within 4 to 10 days, lasting up to 3-4 weeks2."
After that I have been told it remains in bone to some extent and gets released over some years.