Don't expect immediate pain relief like when prednisone takes effect. You might not have any decrease in pain after the first or second infusion or at least I didn't feel any different. I didn't think Actemra was working until I was able to taper my prednisone dose lower without having a flare.

My rheumatologist would have been pleased if Actemra only allowed me to reduce my Prednisone dose down to 3 mg. It took me nearly a year but I exceeded expectations and tapered off Prednisone completely.

I had prednisone induced adrenal insufficiency so an endocrinologist was consulted. It took a long time but eventually my cortisol level improved. The endocrinologist wasn't very optimistic that I would be able to get completely off Prednisone so she was also pleased.
https://www.endocrine.org/clinical-practice-guidelines/glucocorticoid-induced-adrenal-insufficiency
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I took Prednisone to treat PMR for nearly 13 years so adrenal insufficiency was expected. What was unexpected was that my cortisol level improved and I didn't need Prednisone for the rest of my life.

I have now been completely off prednisone for more than 3 years. My symptoms of adrenal insufficiency were similar to PMR symptoms with overwhelming fatigue tossed in. I also had dizziness and "black out spells" but I didn't actually pass out or faint. Prednisone caused me to have high blood pressure and I was on 3 blood pressure medications. After I got off Prednisone, all my blood pressure medications were stopped one by one because of a low blood pressure. Now I'm off all 3 of my blood pressure medications in addition to being off prednisone.

Taking Prednisone for as long as I did caused problems for me. I sincerely hope Actemra works for you! Actemra doesn't work for everyone but it certainly has changed my life for the better.

People say prednisone is a miracle. For me, being able to taper off Prednisone after such a long time was my miracle.