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Has anyone experienced severe insomnia with Evenity?

Posted by tkdesign @tkdesign, Apr 7, 2023

Struggling to find an osteoporosis drug I can tolerate...this felt like my last hope, but after first injection, I literally could not enter any deep restful stages of sleep. Went on for nearly 30 days. Felt like I was going crazy, could not drive or work. Trying to figure out if it were the drug or something else, if I should give it another try.

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yingjichi | @yingjichi | Dec 16, 2024
In reply to @jdshep "I am awake every 3 hrs but I related it to the pain caused by Evenity...." + (show)
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I am awake every 3 hrs but I related it to the pain caused by Evenity. I too must finish my course. I only have 2 to go. Good luck.

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Thanks!

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debhatchell | @debhatchell | Dec 4, 2025

I just had my 4th injection today. Terrible headaches and low energy. My fitness watch shows I've had ZERO to 30 minutes of deep sleep each night. I'm getting hours of light or REM sleep. Sadly, only in Deep Sleep does the body repair itself. Waaah.

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jenniferleigh75 | @jenniferleigh75 | Dec 4, 2025

I am 50 (almost 51) and completed my 12 months of Evenity infusions at the end of October. I had a post treatment bone density scan earlier this week and had significant improvement! 🙂 My lowest/worst T score was -3 prior to treatment and now that score is -2.3. That takes me out of osteoporosis into osteopenia. My other scores are almost within normal range! I just had the IV reclast yesterday so will have a DXA scan in a year to see the progress. I’m am so thankful and happy! I just wanted everyone to know there ARE positive results if you can push through minor side effects. For me, the worst part was fatigue, an increase in headaches, and pain and swelling at injection sites (back of arms) which honestly was the worst of all. It made my arms very sore but only at the injection site where it would swell and make a hard knot. Only lasted 24 hours and improved after the first 6 months. But, this plus the headaches were all easily treated with Ex St Tylenol or Advil if you can take that. It was worth it to me to stay the course. The thought of a future hip or lower back fracture seemed far worse to me than my side effects. I hope this is helpful for some. Blessings!

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debhatchell | @debhatchell | Dec 5, 2025
In reply to @tkdesign "It's rough. My osteoporosis specialist here said no one of her patients had had side effects..." + (show)
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It's rough. My osteoporosis specialist here said no one of her patients had had side effects like that, or any for that matter. First, I don't believe it..many women just tough it out and don't report. Second, just because a doctor doesn't see something in THEIR set of patients, they think that is how it is everywhere. But if a doctor isn't open minded enough to realize their little corner of the world is not the world entirely, or isn't willing to discuss alternatives with you, it's best to go elsewhere for care. I would report your side effects to the drug company that makes Evenity too...they need to know what people are experiencing.

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@tkdesign I agree 100% that one doctor should not make a blanket statement. I love your suggestion of reporting the side effects to Evenity manufacturer. I can sleep, thanks to my incredible night-time cocktail of supplements to promote sleepiness, but my Fitness Watch is not recording any 'Deep Sleep' which is where the body repairs itself. Meanwhile, I'm super fatigued. I am grateful for people saying they struggled with fatigue, too.

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