A Gleason eight is aggressive, but I wonder if there’s something else. Did you check his medical record for Intraductal or cribriform, they are more aggressive things, if found. I know people that are 8’s that has successful treatments. While it is aggressive, it is treatable, normally.

You could ask that somebody else review the slides of his Biopsy to see if there’s more information. Sometimes they change the Gleason score.

Either one of those can be another reason that the cancer is so aggressive. Ask your doctor if that information was not supplied.

Have you gotten genetic testing for him? You should have both ancestry and somatic testing of blood. Is there a history of cancer in the family?