Hi, I have be on HU on and off since 2017. After taking the medication in an hour or so is when I feel the sidd effects which is headache and feeling tired. Since 2023 I am on it continuously. I have been taking 500mg which i managed fine with less headaches and managable tirdness. But 500mg wasn't making that much of difference as my platlates were at 1.3. I have reached out to have a second opinion and was advised to be on 1500mg a day. It was so shocking to me and I was worried how my body would react to it. I discussed it with my regular oncologist and deciddd to start with 1000mg first and see how I feel. I take it at night as the feeling of tired and the headache through out the day was a bit much. My hair falls off when brushing. The good thing is every two weeks my platlates has been going down by 200's so am at 640 now. I have an appointment again in a week so hopefully I will be back on 500mg once it's stabilized. The last three days my headache been feeling like migraine headache. Has anyone been feeling like this?