FWIW, I see PRP as an expensive and temporary fix, with results not guaranteed. If a patient's knee has degraded to this point, a TKR may be a better option.

Some people are concerned about TKR surgery. I think it has a long track record and has become even better with robotic assistance.

The patient has to do both pre-surgery and post-surgery rehab on the knee. It is time consuming and boring. Vigorous rehab goes a long way toward ensuring a good outcome. I'm 70 now, had both knees replaced in 2022 four months apart (Stryker/Mako robotic assistant used) and couldn't be happier about my knees. I spin 5x/week and can do anything in the gym EXCEPT impact exercises - so no running, BB, racquetball, jumprope. I was a marathon runner and miss that from time to time. But my running days were over long before the surgery.