ANA Titer 1:1280 pattern homogeneous and speckled o/w negative work-up

Posted by trspac @trspac, Dec 6 2:26am

Hello. Desperate for help and don’t know where to turn since Rheumatologist stated they don’t know what is causing my symptoms. November 6,2024 first high positive ANA titer 1:1280 pattern homogeneous and speckled with a repeat test on Nov 14,2024 showing highly elevated ANA titer (1:1280) with a speckled pattern only after repeat, alongside negative results for other specific antibodies like anti-dsDNA, anti-Smith, SM/RNP, SCL-70, negative anti-Ro/SSA, negative anti-La/SSB, normal RF, normal C-Reactive Protein, ESR, Folate, Complement C4, Complement C3, Serum Iron, TIBC with low normal WBC, low normal HGB, low Unsaturated iron binding and a normal urinalysis, normal lip salivary gland biopsy with TMJ pain and dry mouth, globus sensation and a feeling of leakiness or fluid coming from the gums, normal parotid ultrasound, muscle aches, and fatigue. Being referred to tertiary care ENT by Rheumatologist since original diagnosis was glossitis after being referred to an ENT initially from Internist for nasal polyps. ENT on Oct 31st determined no polyps and after one look in my mouth said likely systemic due to large tongue and dryness. Tongue only gets swollen if teeth irritation causing sores due to dryness. I have been struggling since Jun 2024. Rheumatologist was kind enough to prescribe pilocarpine with a 4 week f/u but this is with a diagnosis of glossitis unknown etiology. I will start this today, Dec 6,2024. I have an allergy consult next week. I’m just lost looking for direction as my own advocate through this journey. Any suggestions will be greatly appreciated.

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@trspac

@windyshores - I've seen one rheumatologist and would prefer not to doctor hop. I will try and treat on my own for now through juicing and vitamins until I can figure out a better direction. Thanks for remaining hopeful on my behalf since frustration has got the best of me for the moment.

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@trspac that makes sense. I guess it could be a "second opinion"! I find PT's and functional medicine docs to be helpful. I hope you get relief. I totally get your frustration and wild goose chases are exhausting. I truly hope and believe it will eventually work out for you. Fingers crossed!

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@windyshores - I really appreciate the encouragement.

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