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Chronic lymphocytic leukemia (CLL)

Blood Cancers & Disorders | Last Active: Jan 6 9:51am | Replies (17)

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@mereneg

Better to follow up and know what's actually going on than to sit and worry. As @labcoris said, CLL is one of the "best" cancers to have -- if you have it.

My CLL journey started late last year with increased lymphocytes + smudge cells. A medical oncologist initially diagnosed MBL (monoclonal B-cell lymphocytosis): my lymphocyte count wasn't high enough to qualify for CLL, and I didn't seem to have any Sx (symptoms) other than a few enlarged lymph nodes. So, "watchful waiting" was prescribed.

Then, this June, I developed afib (atrial fibrillation). A chest CT (to exclude atrial clots) also revealed numerous lymph nodes and an enlarged spleen. That, and further investigations, changed the diagnosis to SLL (small lymphocytic lymphoma). SLL is a variant of CLL in which the wonky lymphocytes accumulate in lymph nodes instead of peripheral blood.

I recently completed a 6-month course of Gazyva (obinutuzumab) infusions, and am taking oral Venclexta (venetoclax) until next September. Side-effects have been minimal, and I feel better.
Of interest, I recently found an old lab report that mentioned smudge cells way back in 2002! So this has probably been "building" slowly for a long time.

I hope this helps.

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thanks