Hi. Thanks for replying. I've been sick for a year. My symptoms were sjogrens and antibodies were rheumatoid. Plaquinil helped the sjogrens dryness a lot, but doesn't do much for fatigue. I also take tramadol (Ultram), a milder and safer opioid. That eases the fatigue, lightheadedness, and the blues, a good deal, but nothing really gets rid of the autoimmune fatigue. Best wishes to you.