MGUS is considered asymptomatic. If you have excessive fatigue then it would be good for doctors to see if there is anything else going on. Checking kidney and thyroid function, and overall blood/urine tests can be useful. Getting hit with MGUS was depressing for me, and it did take some time to work through the grieving process. I didn't have fatigue so could still escape with nature walks/biking and other interests. It is good to have people you can talk with about what you are going through.