Relapse endometrial cancer

Posted by samaco @samaco, Nov 15, 2020

So, I was diagnosed w/stage 1A grade 1 endometrial cancer in May of 2018. After a laparoscopic hysterectomy, all was fine until relapse diagnosed 3 weeks ago. The tumor didn't even show on MRI, and the PET showed nothing. I am about to start radiation. Is there anyone out there in similar situation now or w/past experience? If so, I'd love to hear from you.Thank you.

Interested in more discussions like this? Go to the Gynecologic Cancers Support Group.

Helen, Volunteer Mentor | @naturegirl5 | Dec 9, 2024

In reply to @riverland889 "Waiting for notification of appt time with Sloan Kettering, and have virtual next week with Mayo..." + (show)

@riverland889 Those are both excellent places to get your second and third opinions. Will you let me know what you learn?

val64 | @val64 | Dec 9, 2024

In reply to @angierivas1 "What is a positive signatera test? I haven't heard of it. Thanks. Hope the new treatment..." + (show)

Just to elaborate a bit, Signatera tests for tumor DNA in your blood. So it can be used frequently for surveillance.

First, the company sequences the DNA from your tumor surgical specimen, looking for mutations, and then it designs a test just for your tumor that detects those mutations.

My impression from reading the pancreas cancer board is that for them, normal tumor markers start to rise significantly before the Signatera comes up positive. I had a different blood tumor DNA test after my cancer recurrence was clearly visible by CT scan, with several sizable tumors, and it didn't detect anything.

So testing for tumor DNA in your blood is a nice idea, but it seems to have a problem with low sensitivity/false negatives in many cases.

riverland889 | @riverland889 | Dec 9, 2024

In reply to @naturegirl5 "@riverland889 Those are both excellent places to get your second and third opinions. Will you let..." + (show)

Yes I will

paz1956 | @paz1956 | Dec 10, 2024

In reply to @riverland889 "It’s a DNA TEST matched to dna of your tumor" + (show)

Has anyone had vaginal brachytherapy right after a hysterectomy? If so did you have a reoccurrence? Or you did not have a reoccurrence?I’m 68 stage1a2 not sure if I want/should get the VB treatments. For some reason VB treatments scare me, terribly

Helen, Volunteer Mentor | @naturegirl5 | Dec 11, 2024

In reply to @paz1956 "Has anyone had vaginal brachytherapy right after a hysterectomy? If so did you have a reoccurrence?..." + (show)

@paz1956 I looked through your earlier comments and could not figure out if you have already had a hysterectomy? Since you know that you are Stage 1a I'm thinking you have already had a hysterectomy as the stage is assigned in the pathology lab by the pathologist who looks at the tissue that was removed during surgery. What does your oncological surgeon recommend?

paz1956 | @paz1956 | Dec 11, 2024

In reply to @naturegirl5 "@paz1956 I looked through your earlier comments and could not figure out if you have already..." + (show)

Hi @naturegirl5, yes I had radical hysterectomy all markers are clear my oncologist surgeon is recommending 4 VB for prevention but for some reason my brain is fighting the treatment. Part of me is wondering if the cancer comes back would radiation be an option? I guess it would depend on the type of cancer, I over think things at times & cancer is very complicated. The other concern is the dilator & you and others reassured me on the use which isn’t that bad. Side effects? Everything scares me & I keep trying for a way out which I believe just do it and pray for the best.
Hope you are doing well!
Thank You for all your help and any additional thoughts

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