Hello joyh

I take 25 mg. of Jardiance a day. I have done so for about 8 years. I am a type 2 diabetic. I experience no discernable side effects from it apart from the fact that it does cause one to relieve oneself more often. Which is what it is supposed to do. (It is not a diuretic but does have some similar qualities.) Therefore, it is a medication one should take early in the morning. I have included a link to explain Jardiance’s role in the treatment of CHF for those who are unaware.
https://www.webmd.com/heart-disease/heart-failure/jardiance-heart-failure
It s my understanding that if one is not diabetic, then a reduced dose of Jardiance is prescribed. I believe the dose is 10 mg.

Like you, I also take Entresto. While there is some overlap, (reduction of fluid) Jardiance and Entresto work in very different ways .
The two active substances in Entresto, sacubitril and valsartan, work in different ways. Sacubitril blocks the breakdown of natriuretic peptides produced in the body. Natriuretic peptides cause sodium and water to pass into the urine thereby reducing the strain on the heart. They also reduce blood pressure and protect the heart from developing fibrosis (scar tissue) that occurs in heart failure. Valsartan is an ‘angiotensin-II-receptor antagonist’, which means that it blocks the action of a hormone called angiotensin II. The effects of angiotensin II can be harmful in patients with heart failure. By blocking the receptors (targets) to which angiotensin II normally attaches, valsartan stops the hormone’s harmful effects on the heart and also reduces blood pressure by allowing blood vessels to widen.
Jardiance works by reducing the amount of fluid in your bod, thereby reducing the load on your heart.
I was prescribed Jardiance before I received my diagnosis of CHF. The cardiologist I attend informed me that if I had not already been on the medication, he would have prescribed it for me. He said that it has become one of the important medications in the treatment of CHF and has shown itself to be highly effective for the very reasons you point out, Joy.
Unlike Ozempic, I don't believe Jardiance is seen as a weight loss drug. But then again, that was not the original intended use for Ozempic, either. (I take it as well and not for weight loss.)
I find it encouraging and more than a little fascinating that more and more so called "off label" uses are being found for established medications. One should always keep in mind that this is not new. Once upon a time, the famous “little blue pill”, was developed as a cardiac medication to help reduce ischemia-induced arrhythmias. Then it was noticed by the powers that be that the medication had this other, uh, “interesting” side effect, and Viagra was born.
So, in closing, as someone who has a CRT-D and is in end stage CHF, it is important to me to help my heart do its job as well as it can. Medications are one part of the equation.
Wishing you the very best of the season.