At times I get itching. Right now I don't have it. It's usually worse in the winter months so I try to use a cream most days like Aleavia. That one is very soothing. If I get itchy and get any hives it can be unbearable and the dermatologists really didn't have any suggestions other than a $1000 per month shot and I didn't want to spend that plus I thought it might have dreadful side effects. I find marijuana edibles to be very helpful. If you are not used to it start small and you can build up to the dose you need. I usually take 1/3 to 1/2 of a 10mg THC edible. You can use Sativa during the day and Indica type for. night time. I purchase ones that are solvent less and don't have preservatives or any food coloring nonsense. I've been enjoying the Lilly Brand but it depends on the state you are in and the region what you'll be able to purchase. When I take the edible I am still itchy but it doesn't bother me and the Indica type helps me sleep without scratching. It makes it much more bearable. It will take about an hour to feel any relief. The only reason I take Allegra is not for the itch (it doesn't help me with that) but because I suspect I might have mast cell disorder. I had a severe case of Lyme disease and I've read that 50% of people with Lyme end up with mast cell disorder where the mast cells (immune cells in the body) become dysregulated and they spit out chemicals when they don't need to, like cytokines, etc. I know someone who was diagnosed by a mast cell specialist and they recommended H1 blockers (like Allegra) and H2 blockers (like Pepcid) to calm down the immune overreactions. I started taking it and changing my diet to a low histamine diet for a period of months and it seemed to work. I now feel good most of the time and have an occasional flare up which could last a week or two but the frequency of the flareups has decreased and I feel much better generally. I also believe I could possibly have some of the genes that cause Ehlers Danlos Syndrome so that might be a contributing factor but I haven't been diagnosed. I have some kind of mild type because I don't have the extreme symptoms of the syndrome. When I exercise strenuously my muscles seem to become inflamed, tighten up, and hurt horribly. and the don't relax easily and I become arthritic for a time until they calm down. Anyway, try the marijuana edibles in a low dose to help with the itch. I don't drive when I take them. I take them usually in the evening before bed when needed.