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Anyone having flareups of PMR after stressful situation?”
Polymyalgia Rheumatica (PMR) | Last Active: Dec 8, 2024 | Replies (14)Comment receiving replies
There is some evidence that inflammation via cytokines affect the brain.
There are also findings of improvements in reduction of cytokine levels
by SSRI anti- anxiety drugs in the medical literature. I have wondered
how chronic occult systemic inflammation affects the nervous system.
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My rheumatologist often used the terminology "systemic inflammation" instead of PMR. The association of PMR to GCA makes me believe there is a vascular connection. I like the following definition of systemic inflammation because it talks about a "cascade of chemical reactions" and how WBCs "patrol" while looking for things to attack. In the case of autoimmune disorders, the attack is mistakenly on our own tissues.
"What is systemic inflammation? Systemic inflammation, or full-body inflammation, is the body's response to stress, such as illness or trauma. This process is a cascade of chemical reactions that elicit a response on the cellular level. The white blood cells (WBC) in the body, called leukocytes, patrol the different areas, looking for infection. When they notice signs of trauma, they increase in number and rush to heal the area."
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In addition to PMR, I was a neurology/neurosurgery nurse. I also have trigeminal neuralgia, peripheral neuralgia and severe spinal stenosis. I'm very interested in the nervous system!
The following link is complicated but on the right hand side you can click on whatever interests you. You could also go to the bottom of the list and click on "conclusions."
https://pmc.ncbi.nlm.nih.gov/articles/PMC10419139/#sec11-ijms-24-11902