Dosage Adjustments On Tymlos Pen

My doctor, the company and the pharmacist all told me that it is fine to use it past 30 days if it is refrigerated the whole time.

I have been using Tymlos for almost 3 weeks. I didn't know that I could lower the dose and started with 80 and my heart went wild, pounding and pressure/pain. This forum suggested I go to 40 (4 clicks) and I have been doing that but my heart is still thumping and irratic for about an hour after taking it. I am currently wearing a holter monitor and will see what cardiology has to say today. I would not increase to 6 yet if I were you. Stay on 4 clicks (40 mcg) for several days to see if the effect on your heart lessons. Good luck.

Beanieone,
I don't think the pens last much longer than 30 days. I was on 2 clicks and used the pen for 60 days. When I started the next pen all of my side effects came back, so I figured it was stronger. I always refrigerate. Now I'm on 4 clicks and only let it go afew days or a week past 30 days, and I can't tell any difference with the new pen.

@zygote maybe you could go down to two clicks for a week or two and move up more slowly.

I used pens for 5 weeks. With the approval of doc, and Radius. But only if refrigerated and I kept it cold when I visited kids with cold packs and cooler (wrapped the box in a hand towel).

Hi,
I have really appreciated the info about starting with a lower dose, letting your body adjust. I did my first dose today. I believe I was one click below the full 80mg dose. But I didn’t feel anything. No dizziness, no rapid heartbeat, no headache or nausea. I will try again tomorrow at the same dose.

@fresuab1 if you have no reaction to 70mcg that is great! I had 20% gain in my spine on that dose. You will probably be able to do 80 anyway.

Well, I may not have judged the clicks correctly. I will go more slowly next time. I went all the way to 80 and then to what I thought was one click down from there.

I also requested the extra fine needles based on advice I found here. I hardly felt the injection, which was nice.

I just started Tymlos a week ago and this is the first I've heard of adjusting the dose with "clicks" on the pen. Are there any instructions from Tymlos?

no, @hudsonlady, you have to get the instructions here from @windyshores.

@hudsonlady many people don't need to start at a low dose of Tymlos. It's fine to start with a full dose or half dose and see how you do. Ramping up with dose adjustments may not eliminate side effects either: for me starting low and moving up on dose made it possible/tolerable to do.

This is not a studied protocol and the company, Radius, is not going to recommend it. Many doctors won't either. I think I brought the idea to the forum a few years back but never intended everyone to do it or to suggest that folks should stay at a lower dose to avoid all side effects.

My doctor has patients do this when necessary rather than quitting- which I almost did! He watched me try to get on various meds over 16 years and was happy that anything helped!

As for instructions: it is very individual. I tried a half dose and has trouble. I went down to two clicks and maybe every week or so went up a click. I ended up at 7 clicks most of the time, and 6 if I had something important to do. Oddly I could never tolerate 8 clicks (I did that maybe three times total in two years).

ps We are all increasing Radius' business since some of us would have quit!!!!