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Alpelisib (Piqray): for anyone starting this medication
I’m posting this update to my original post re: Piqray so that maybe it will be helpful to women who are starting this med. I was not able to find posts related to this treatment.
I”ve been on Piqray ( Apelisib) for 1 month in combination with monthly Faslodex injections after having been on Ribociclib/ Faslodex for 15 months with new liver mets. This drug is specific for breast cancer patients with a PIK3 mutation of which I have. The most common side effects are hyperglycemia and diarrhea. Prior to starting this med I tested my fasting glucose via glucometer daily for a week to establish a baseline, then daily for the first two weeks once I began Piqray. My fasting blood glucose continues to be within normal limits and I test a few times a week. I’m wondering if the incidence of hyperglycemia increases over time. The GI symptoms have been manageable with Immodium as needed.
Here’s a link that I found very helpful in explaining this mutation.
https://www.verywellhealth.com/pik3ca-mutations-in-metastatic-breast-cancer-4689488
Thanks for reading.
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Thanks for posting and sharing your experience. It is good to hear that you are managing. Do keeping touch as you continue.
Hello @hikerlou I am glad to hear that the side effects are manageable. I am very enthusiastic for the new drugs that will target gene mutations instead of just hitting all the fast growing cells in our bodies.
Do you have a plan for timelines of imaging to check up on those liver Mets?
Yes. I have CT of chest and abd, and MRI of abd scheduled for January. The CA 27.29 antigen has been a good indicator for me and will continue following that as well.
Thanks for asking. Have a happy holiday.
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1 ReactionHi, my mum should soon start with Alpelisib - Piqray therapy. She used Ribociclib and Fulvestrant for almost 2 years prior to this. Please share your experience with this medicine, side effects, how to manage as well as results of the therapy.
Welcome, @amina116. I moved your post about alpelisib (Piqray) to this discussion to connect you with @hikerlou @murrayann @tdesantis and others.
- Alpelisib (Piqray): for anyone starting this medication
https://connect.mayoclinic.org/discussion/update-on-piqray-therapy/
Amina, when will your mother start the new treatment? How is she doing?
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1 ReactionHi Amina 116,
Please see my first post above re Piqray. Like your Mom I’ve been on the Ribociclib/ Faslodex combo. It worked for 15 months. I’ve been on Piqray for almost 2 months. No rebated blood sugars. YET. I’ve had a few bouts of diarrhea but that seems to have stabilized. I have noticed mouth sores and a metallic taste in mouth. Please let me know how your mom is doing on this med. There aren’t a lot of women on it.
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2 ReactionsThank you for posting this information. I just had my first injection of fulvestrant and will soon be starting PIQRAY. I’m worried about the diarrhea and vomiting. How have you been coping? Thank you.
dale
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3 Reactions@nwhmbc, just checking in. How are you doing on treatment?
Hi.
Thanks you for checking in. The injection was fine. Other than a little tenderness in the area of the injection I feel good. I have my second one on the 22nd. My doctor delayed the start of PIQRAY as my glucose was high. The plan is to start me on a 7 day med and then start PIQRAY. I’m having a spine and skull MRI on Saturday and they want to see the results of that. I fell like I need an Excel spreadsheet to keep track of it all. How are you doing? Did you start the PIQRAY? How are the side effects? Take care.