@ripley I had already done 2 years of Tymlos and initially thought that if I had side effects on Evenity I would try to do the early months when anabolic action is stronger. I went on Reclast after Evenity. I did have some neuro symptoms (chest and forearms burning) on Evenity but I mainly wanted to top off Tymlos with a burst of P1NP and save 8 months of Evenity for later. This is NOT an approved protocol.

A study was posted about doing 6 months Evenity then going on Reclast rather than doing the last 6 months of Evenity, since both are anti-resorptives. It is still ongoing.
I read that the initial pre-market expectation with Evenity was that it would be anabolic the whole time and the fact that it isn't, was a surprise once it went on the market.

I saw another study proposing short bursts of Evenity between other drugs, like Reclast. All of this research is ongoing since Evenity is so new (2019).

My friends who did the full year had remarkable gains on Evenity. I have a DEXA in April but will never know what those 4 months did since I have been on Reclast. My doc says they don't really know how Evenity works (it inhibits sclerostin of course). IF I were a newbie and doing my first drug I would do the full year.

I am in this for the long term with 7 spinal fractures. Some may do Evenity, a year or two of Reclast and be done. That is not me! Again, most of what I have done is individual, not established protocol and since I have kidney disease, lupus and afib my doctors tend to be flexible with me.