Anyone had Immunotherapy or Maintainance Therapy when HRD Negative?

Posted by doshi @doshi, Nov 19 4:35am

I’m reaching out to connect with anyone who may have experience with a similar cancer diagnosis or treatment journey, as my wife has recently been diagnosed with Stage IIC Ovarian/Endometrial Cancer.
The doctors were unable to definitively confirm whether the uterus or ovary is the primary site of the cancer. We learned about the diagnosis after my wife underwent surgery to remove her uterus, both ovaries, fallopian tubes, and a lymph node from her right pelvis. Unfortunately, all of the tissue samples came back positive for cancer, and the lymph node was classified as Grade 3.

This has been an incredibly difficult time for us, especially since my wife is only 41 years old, and we have two young daughters, aged 10 and 7. Following her surgery, she was offered six rounds of chemotherapy and radiation therapy afterward. We’ve just completed the second round of chemotherapy, and she is managing okay, though she’s experiencing some side effects.
Last week, we received the results from a germline test, which showed that she is HRD negative, as well as negative for BRCA1/2 and other mutations.
Given this, I’m reaching out to ask if anyone has encountered a similar case and whether you might have suggestions for any treatment after or along with chemo, as immunotherapy or other approaches, that have shown promise. Any insights, advice, or personal experiences would be incredibly appreciated as we continue to navigate this challenging journey.

Thank you so much for your time and support.

Interested in more discussions like this? Go to the Gynecologic Cancers Support Group.

@doshi

Does anyone has any experiance and idea for above?
Can somoene please help with details if you have gone through similar journey?

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The problem with cancer is that it is possible for one cell to grow into a tumor, but there's no way to detect one cancer cell. After cancer surgery, it's usually not possible to detect any remaining cancer using the tests that are available, but that doesn't mean that there aren't still a few cancer cells lurking there. So they do chemo and/or radiation hoping to kill any remaining cancer cells, even though they don't know whether or not there are actually any still there.

So there's no way to tell whether treatment worked or not. If the cancer doesn't come back, either the treatment worked, or it wasn't necessary in the first place. You only know it didn't work if the cancer comes back.

Was that your question?

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@val64

The problem with cancer is that it is possible for one cell to grow into a tumor, but there's no way to detect one cancer cell. After cancer surgery, it's usually not possible to detect any remaining cancer using the tests that are available, but that doesn't mean that there aren't still a few cancer cells lurking there. So they do chemo and/or radiation hoping to kill any remaining cancer cells, even though they don't know whether or not there are actually any still there.

So there's no way to tell whether treatment worked or not. If the cancer doesn't come back, either the treatment worked, or it wasn't necessary in the first place. You only know it didn't work if the cancer comes back.

Was that your question?

Jump to this post

Thank you @val64, yes that help understand about test etc.
I am also looking for someone who is pMMR and HRD negative to understand what type of treatment they had and what was experience.

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