1. < Osteoporosis & Bone Health

Tymlos vs. Evenity

Posted by eliz4142 @eliz4142, Mar 8 2:31pm

Hi all. I experienced a compression fracture at L1 about 4 weeks ago and this is how I learned I have osteoporosis. I'm "only" 57 and, after having a lot of blood work done, there is no explanation for my bone loss. I was adopted, so I don't have a lot of information about my genetics. Seems it's just an unusual (though not unheard of) situation. Since I've experienced a fracture already, my doctor has advised me that I need an anabolic agent. I'm trying to decide between 24 months of daily Tymlos or 12 monthly injections of Evenity. The doc assures me both are really effective. Evenity seems to have some serious (though unlikely) side effects, but definitely seems like a more palatable regimen. Any thoughts or experiences that might help me decide would be appreciated! Thank you!!

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alice75 | @alice75 | Apr 5 2:49pm
In reply to @michaellavacot "I have been taking Prolia since late November 2023. No side effects so far. I did..." + (show)
@michaellavacot

I have been taking Prolia since late November 2023. No side effects so far. I did get a blood test done at the one month mark and saw a drop in calcium from about 9.5 to 8.9, so I upped my calcium intake and extra 200mg. Rechecked a month ago and now at 9.3. I also saw a drop in my urine calcium by ~ 100mg/24 hours, which was good and expected. Because I have hypercalciuria, I am ensuring consistent calcium intake to maintain stable blood calcium. Prolia makes it so calcium is not as readily available from the bones. Hypocalcemia has some ready bad effects on the body.

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Thank you for input. I have not started on Prolia yet and am hesitant to due to some of the affects as you mentioned.

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cdetjen3 | @cdetjen3 | Aug 15 3:25pm

During the first three months I experienced pain in my quads especially when I climbed stairs. Sometimes when I ran, my right hip would have a shooting pain. I was able to walk it off.
Around the ninth month I had heart pains. An EKG indicated no problem. This pain recurs. It is similar to the pain I used to feel when I consumed caffeine. I have dense breasts and no longer consume caffeine.
I have three months left.

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happy2023 | @happy2023 | 1 day ago

I am 77, have had 2 spinal compression fractures six months ago, and diagnosed with Osteoporosis 2 months ago.
Because of the results of my 24-hour urine test, the endocrinologist has ruled out Tymlos and Forteo, instead prescribing Reclast with once yearly infusion for 5 years. I will begin treatment soon.
I'd like to ask if anyone has taken Reclast and if it has helped and also did it cause you any side effects.

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1 reply
windyshores | @windyshores | 17 hours ago
In reply to @happy2023 "I am 77, have had 2 spinal compression fractures six months ago, and diagnosed with Osteoporosis..." + (show)
@happy2023

I am 77, have had 2 spinal compression fractures six months ago, and diagnosed with Osteoporosis 2 months ago.
Because of the results of my 24-hour urine test, the endocrinologist has ruled out Tymlos and Forteo, instead prescribing Reclast with once yearly infusion for 5 years. I will begin treatment soon.
I'd like to ask if anyone has taken Reclast and if it has helped and also did it cause you any side effects.

Jump to this post

@happy2023 if you have fractures, I am wondering why Reclast is being prescribed. Do you know? Ask your doctor about Evenity, which can act fast to actually build bone, at least n the first months. I have a friend who went from -4.1 to -2.5 which is an incredible gain.

Evenity is generally followed by Reclast which can "lock in gains" from Evenity and continues to build bone by lowering turnover.

The problem with doing Reclast now is that 1) it won't build new bone the way Evenity does and won't work as quickly as Evenity 2) it will reduce effectiveness of Evenity in the future (according to McCormick's "Great Bones" and various videos including those of Dr. Ben Leder).

I did Tymlos then Evenity (4 months) and am now on Reclst. It does build bone density. My friends all do fine on it. There are side effects for some. Many of us have a fluish reaction to the first infusion but that tends not to recur.

I hope you can talk to your doctor about Evenity. I also have fractures so I can relate!

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1 reply
happy2023 | @happy2023 | 7 hours ago
In reply to @windyshores "@happy2023 if you have fractures, I am wondering why Reclast is being prescribed. Do you know?..." + (show)
@windyshores

@happy2023 if you have fractures, I am wondering why Reclast is being prescribed. Do you know? Ask your doctor about Evenity, which can act fast to actually build bone, at least n the first months. I have a friend who went from -4.1 to -2.5 which is an incredible gain.

Evenity is generally followed by Reclast which can "lock in gains" from Evenity and continues to build bone by lowering turnover.

The problem with doing Reclast now is that 1) it won't build new bone the way Evenity does and won't work as quickly as Evenity 2) it will reduce effectiveness of Evenity in the future (according to McCormick's "Great Bones" and various videos including those of Dr. Ben Leder).

I did Tymlos then Evenity (4 months) and am now on Reclst. It does build bone density. My friends all do fine on it. There are side effects for some. Many of us have a fluish reaction to the first infusion but that tends not to recur.

I hope you can talk to your doctor about Evenity. I also have fractures so I can relate!

Jump to this post

Thank you for your reply, Windy Shores. My 24 hour urine test precluded me from using Tymlos, which my endochrinologist talked to me about at my first visit.
I'll ask about Evenity before Reclast.
All the medication out there for Osteoporosis is mind bending. And the side effects are worrisome.

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