@jeff1047 I was looking at the article you referenced which had this in the discussion.

"Although we cannot rule out an allergic response to mold, and certainly there are people for whom mold is an allergen, the responses observed in this study fit the innate-immune-activation model."

I am not sure I understand the difference between an allergy and an innate immune activation. I know I am very allergic to mold and it triggers my asthma and sinus irritation. It does cause swelling in my nose, sinuses and lungs, and I need to treat my asthma with inhalers. I have done allergy shots for a lot of allergens including molds, but I'm lazy about doing it, so it's often easier to take an antihistamine, but that isn't enough if there is a significant exposure. Just driving through an agricultural area a couple days ago, I thought I was getting sick with breathing issues and a sore throat. After I got home, those symptoms cleared a lot when I got back into the filtered air of my home. With asthma, my blood oxygen levels vary depending on my lung condition which can make me very tired.