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@jheieck

I just came across this forum and have a very similar question, experience. I have been on Prolia for 6 years and was put on it without consulting me about potential dental issues. After a year or two I discovered that I would have problems having dental work. At the time I already had about 15 crowns and a bridge and three root canals so I'm surprised I was even prescribed Prolia. Now I'm at a point where my parathyroid is starting to the elevated, as well as my blood calcium. I have only been seeing a bone health specialist, nurse practitioner, for 6 years that I've been on Prolia. I recently had a failed bridge and had to have a bone graft which took just fine. I was told I could have dental work, two implants installed, approximately 4 months after my last Prolia injection, which I did. After 2 weeks the bone started to erode in my jawline where the implant was located so my oral surgeon removed both implants and I am in the process of healing now. Due to my elevated parathyroid and my strong feeling that I should no longer be on prolia, we are searching for answers to what I can transition to an off from Prolia. Seem to be caught in a very big catch 22 situation, with regards to what medication I can take into whether I can ever have my dental work completed. I have now made an appointment to see an endocrinologist as well as a rheumatologist, to explore what would be the best course of action. I am postmenopausal and had a hysterectomy at age 35 so I don't know if some of the oral medications will work for me? I was told reclast is not an option for me because of the potential damage to my jaw. My bone health specialist is recommending Evista but I don't like the side effects that I'm reading about. Does anyone have any input as to what might work in my situation? Something that I can transition to so that I can get off of Prolia, without damaging my jaw any further? I've been told I cannot just call turkey off Prolia and also that I may never be able to have dental work again, meaning I will be missing three teeth on the lower right side of my mouth? I am very depressed about my lack of options at this point. I am bound and determined to not continue Prolia any longer I think there are other side effects of experiencing due to the length of time I've been on this drug.

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Replies to "I just came across this forum and have a very similar question, experience. I have been..."

As you know, after many years' treatment of prolia, AFF or ONJ could occur although incidences are very rare. You don't have either but if you are planning major dental work while dealing prolia withdrawal at the same time, you most certainly need a bisphosphonate to deal with the potential rebound effect from prolia withdrawal (to prevent potential VCFs); also likely you'd need either tymlos or forteo to help building/healing of jaw bones from oral graphs.

Here is a previous thread in which many members discussed a similar case of prolia withdrawal with the presence of AFF:
https://connect.mayoclinic.org/discussion/the-doctors-reply-after-prolia-aff-and-now-recommends-forteo/
Wish you the best!