What are most common side effects when starting HU (Hydroxyurea)?

I started out taking HU 1x week for a month, 2x week for 8 months, and this week, at the one-year mark of my ET/Jak2 diagnosis, I am taking it 3x week. I have fatigue and dry skin. If you are taking HU daily, maybe a slower intake might help. My platelets started at 780K a year ago at age 69. Mine have gotten down to 500K, but they recently jumped to 580K, so I am taking HU 3x week. I also take daily iron and baby aspirin. My general blood work related to RBC has also improved.
Take care,
Karla

I've been on Hydroxyurea since 2021. I was 69 when diagnosed with high platelets - 800,000 in a routine blood test and a bone marrow biopsy confirmed ET. The hematologist put me on Hydroxy starting at 3 doses a day (500 mg/pill) then a blood test, then dropped to 3 one day, 2 the next, then a blood test, and after 6 weeks of testing I was finally stable under 400,000 platelets. Now I'm at 2 pills a day for the last 3 years. I had no real side effects, maybe a little fatigue. I am moderately active, walking almost daily and doing some other exercises once a week. I take the 2 pills with a glass of water before breakfast and that has not given me any stomach trouble. I stopped taking baby aspirin because my mother had stomach problems and I am more sensitive to some foods now. I put on gloves before handling the pill bottle and pills (disposable gloves are everywhere now thanks to Covid). I wear a hat and put on sunscreen anyway as the sun here in NM is intense and I'm fair-skinned.

I was on HU for 24 years. Only side affect was fatigue and yes- thinning hair.
Then I developed a bad case of locally advanced skin cancer on my head. As you know, on HU, you are sensitive to the sun and should be diligent with sunscreen all year round. But who put sunscreen on their head? I didn’t.
I was able to control it with a topical cream that took 6 months to eradicate it but I scared me off of HU. Please all- use sunscreen.

I am now on Anagrelide. I had no previous heart issues so it works for me.
Yes, it initially gave me some heart palpitations but my body adjusted.
I also take nicotinimide which works to thicken my hair and has been shown to be helpful in keeping skin cancer at bay. I am 66.
Was diagnosed with ET at 39.

Is anyone on this list serve taking any of the new weight loss drugs along with HU? What has been your reaction?
Thanks. Linda (I have ET and take 500 mg HU per day.)