Hello @zeedee1 I would always follow my doctors orders if it is a doctor I feel I can trust. If you don’t feel like you can trust this doctor then I would get a second opinion. We got my husbands second at Mayo, then that doctor coordinates with our local doctor for the best care possible. You said you were diagnosed 6 months ago, what was that diagnosis? Can you please explain more about your diagnosis, did your numbers start climbing when you stopped Imbruvica or are you still on it?