Hi @junecc . You didn't specifically ask me about this but I will chime in anyway. I started Camzyos just over a year ago at age 59. I have never had any side effects whatsoever. I've been on Omeprazole for something like 10 years. I **think** both Tagamet and Omeprazole are used to treat the same kinds of problem. Omeprazole was one of the medications explicitly referred to in the Camzyos warnings. I had several conversations with my cardiologist, my pharmacist, my family doctor and my Camzyos REMS program nurse case manager, and all of them advised that, in my case, I could continue the Omeprazole while taking Camzyos but that I should (i) watch out for any problems - of which there have been none - and (ii) take the Omeprazole in the morning and the Camzyos at bedtime. I have no medical expertise and you should not take this as advise for you - listen to your experts, not the internet - but in my case there have been no issues except that I am no longer allowed my beloved grapefruit. Good luck with your treatment!