Hi @nancy2952, welcome to Connect. I'm tagging fellow members @karenatmayo @sistie @rae3 @194719731977 and @wandering, who have had one or more of the 3 drugs you are taking: Ibrance and letrozole and Xgeva.

Nancy, how long have you been on this regimen? How are you feeling?

Hi, Nancy. I am 69 and on the same drugs (iBrance, letrozole, Xgeva injections) as you are for a year now. (I also had whole brain radiation for MBC to the brain in addition to spine and pelvic.) The iBrance has made things "stable" for now so hoping for the best for now. I had Stage II breast cancer and all the treatment that goes with that 18 years ago and was fine until MBC diagnosis last year, which includes anemia, causing me to feel weak and tired much of the time.

Hi @nancy2952 i have been on that exact mix since november 2017. For me totally doable. Lots aches, but stretching helps. I have insomnia too, but sleep meds also really help - either ambien or melatonin. I was diagnosed with BC june 2016, chemo, radiation, surgery. October 2017 saw it metastasized to my spine. Holding study since starting this mix of meds. I am 39 ueras old.

I have only been on the Ibrance for 21 days. After the week off my blood work showed that my white cells were low. And my doctor told me to stop for a week. I have been feeling OK. Only side effect so far is my hair has been falling out.