Hi @firecracker! I have a similar drug profile which started back 24 yrs ago. Did Evista for 3 yrs, about 7 yrs of Actonel followed by a 13 yr drug holiday, then Fosamax for 2.5 years and last year a Reclast infusion which if the scan is correct greatly improved my spine. While my endo seems to think Prolia is next, I don't. Hope to do a drug holiday until my spine goes South and then go to a bone builder. I'm encouraged by your post. Prolia might be an option in 10 yrs when I'm 88 but maybe by then there will be something new.