@firecracker that adds up to 15 1/2 years on an anti-resorptive! Are you doing Reclast after Evenity? I wonder if all those holidays mean less risk (of atypical femur fracture, jaw necrosis) from doing more years of a bisphosphonate. Now they are saying to limit to 3-5 years but it seems unavoidable to do more than that given the need for bisphosphonates after other drugs. I am curious how thinking on this might be evolving: drug holidays enabling further use of bisphosphonates past 5 years.

@firecracker i really appreciate that you share your experience in detail. Your bmd improvements from Evenity therapy are remarkable even after lengthy treatments of two bisphosphonates. Information regarding how well anabolics work after Reclast are relatively lacking from well designed studies, your personal experience sheds some light for those of us who are figuring out long term treatment planning. Thanks again and best wishes.

Hi @firecracker! I have a similar drug profile which started back 24 yrs ago. Did Evista for 3 yrs, about 7 yrs of Actonel followed by a 13 yr drug holiday, then Fosamax for 2.5 years and last year a Reclast infusion which if the scan is correct greatly improved my spine. While my endo seems to think Prolia is next, I don't. Hope to do a drug holiday until my spine goes South and then go to a bone builder. I'm encouraged by your post. Prolia might be an option in 10 yrs when I'm 88 but maybe by then there will be something new.

@firecracker That's just amazing getting great improvements in both spine and hip after all those years of bisphosphonates. Just Amazing!
Congratulations!!!!!!!!!