1. < Breast Cancer

Reduce dose of exemestane

Posted by jchato9 @jchato9, Nov 4 8:17am

After 3 months of debilitating joint pain with exemestane, I was told to try another AI. I don’t believe it will be better. So I researched if different dosage could be as effective and I found that research: Alternative Dosing of Exemestane Before Surgery in Treating Postmenopausal Patients With Stage 0-II Estrogen Positive Breast Cancer . : Conclusions and Relevance: In this randomized clinical trial, exemestane, 25 mg, given 3 times weekly in compliant patients was noninferior to the once-daily dosage in decreasing serum estradiol. - I am going to try this instead of stopping completely AI

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windyshores | @windyshores | Nov 4 8:37am

Exemestane is different from the other AI's.

The drug insert for letrozole says that a 20% dose is effective.

The thing is, if they are effective, that means estradiol has been reduced below detectable levels so wouldn't side effects be the same?

I started with anastrazole, switched to generic letrozole, had side effects, switched to brand name and tolerated. Sometimes it is the fillers in the med, but it sounds like for you switching manufacturers won't help. Still exemestane is different in the way it works so maybe trying anastrazole or letrozole might help. My doctor allowed alternate day dosing with letrozole though I never did it.

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jchato9 | @jchato9 | Nov 5 8:17am

The study was done with women median age of 66. who can’t tolerate daily adjuvant treatment. I am 71, my joint pain was mostly blamed on arthritis but when I stopped no pain!! Pharma loves to medicate but less can be effective . Quality of life!

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thora902 | @thora902 | Nov 5 12:48pm

I have been taking Exemestane every other day. I have read that study as well.

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1 reply
brightside21 | @brightside21 | Nov 9 12:17pm

Could you sent the link for the research papers you found id like to read the full article & particury the 8nfo saying x3 times a week still worked

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2 replies
anjalima | @anjalima | Nov 10 8:44am
In reply to @brightside21 "Could you sent the link for the research papers you found id like to read the..." + (show)
@brightside21

Could you sent the link for the research papers you found id like to read the full article & particury the 8nfo saying x3 times a week still worked

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Following

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jchato9 | @jchato9 | Nov 12 12:22pm
In reply to @thora902 "I have been taking Exemestane every other day. I have read that study as well." + (show)
@thora902

I have been taking Exemestane every other day. I have read that study as well.

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Less side effects such as joint pain !

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1 reply
jchato9 | @jchato9 | Nov 12 12:23pm
In reply to @jchato9 "Less side effects such as joint pain !" + (show)
@jchato9

Less side effects such as joint pain !

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I meant do you have less joint pain?

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1 reply
thora902 | @thora902 | Nov 13 6:29pm
In reply to @jchato9 "I meant do you have less joint pain?" + (show)
@jchato9

I meant do you have less joint pain?

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I am not sure. I know that I was put on Exemestane because I could not tolerate Anastrozole.
I am shedding like crazy. My hair is really thin...

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