Here’s a simplified overview of CAMZYOS's mechanism in reducing septal thickness:
Camzyos belongs to a class of drugs called cardiac myosin inhibitors. Camzyos' mechanism of action (the way it works) is to block the activity of a certain protein that helps your heart muscle contract (squeeze). By blocking this protein, Camzyos relaxes your heart muscle.

Myosin Inhibition: CAMZYOS selectively binds to cardiac myosin, decreasing the interaction between myosin and actin filaments within heart muscle cells. Myosin and actin are crucial for muscle contraction, so by reducing their interaction, CAMZYOS decreases the force of contraction in the heart muscle.

Decreased Hypercontractility: In hypertrophic cardiomyopathy, the heart muscle tends to contract too forcefully, leading to increased workload and progressive thickening of the septum. By reducing the force of contraction, CAMZYOS allows the heart muscle to relax more effectively, which reduces the abnormal pressure and stress on the heart muscle.

Reduction in Septal Thickness Over Time: By decreasing the excessive contraction, CAMZYOS helps to "unload" the heart, leading to a gradual reduction in septal thickness. This happens because the heart no longer has to work as hard to pump blood, allowing the septum to return toward a more normal size.

Improved Blood Flow: With the septum's reduced thickness, CAMZYOS alleviates the obstruction in the left ventricular outflow tract, making it easier for blood to flow out of the heart and reducing symptoms like shortness of breath, chest pain, and fatigue.

In summary, CAMZYOS reduces septal thickness by decreasing the heart's excessive contractility, relieving the stress on heart muscle cells, and allowing the septum to reduce its diameter thickness and resizing to an smaller diameter.