Hi, no I've not experienced any symptoms but I increased very very slowly. Is there a reason you are on the highest dose? The way it works is the lower the dose that os helpful, the better. Ot can take months at 3mg, like 6, to see if that will help. Then increase by .5 every several months. It should take almost a year to need to go as high as 4.5. That may be too high for you. The quicker the highlife is reached and endorphins kick in, the better. Like 2 or 3 hours of halflife is best. Achieved by lower dose. Best of luck. Have ypu added other meds at the same time. You can't take any opioids on it. Be