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Kappa light chains: What does this mean?

Blood Cancers & Disorders | Last Active: Nov 18 8:34am | Replies (11)

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@kayabbott

I've had IgA kappa light chain MGUS for 8 years (I'm 70). My current kappa is about 300 and kappa/lambda 29. Your bloodwork may also deficient in B12, which is one factor in iron deficient anemia and gastrointestinal syndromes/diseases. Progression of MGUS to SMM (smoldering multiple myeloma) or MM is about 1% each year, so it stays at MGUS and asymptomatic for most people. It is good to get the flood of doctors and tests done up front so there is more info on potential causes/fixes. It would also be useful to check with a gastroenterologist because celiac disease, colitis, and other GI problems can also impact iron absorption/use. I have celiac and colitis, which are controlled by diet (it is good to keep a food journal to see if you have any food intolerances). https://www.nhlbi.nih.gov/health/anemia/iron-deficiency-anemia Here are links to MGUS: https://www.myeloma.org/multiple-myeloma-anemia https://pmc.ncbi.nlm.nih.gov/articles/PMC3904304/

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Replies to "I've had IgA kappa light chain MGUS for 8 years (I'm 70). My current kappa is..."

Thank you for your response. I will definitely be discussing all of this with my hematologist. He did bloodwork for celiac disease and it was normal. Cat scan is what found the kidney stones. When he saw me on 10/22/24 I had virtually no iron, even after taking iron supplements for a month. Definitely going to stay on top of this.