More research, more rabbit holes!!!! 🐇🐇🐇

Apparently, there may be different manifestations of CSVD arising from different causes. Microbleeds tend to occur in amyloid-related CSVD (e.g., Alzheimer’s), while WMH and lacunae predominate in arteriosclerosis (as in diabetes and hypertension). Genetic mutations may also have their own characteristics, such as the lacunas in CADASIL. AF itself has many possible causes. So many confounders, it is hard to know where AF begins and CSVD ends, or how the sequelae of a catheter ablation may contribute to brain function.

It’s nice to know that those who have had a successful CA tend to do better cognitively than those just treated with medications, but we really don’t have a handle on some of the after effects—or how someone with CSVD may respond longterm to such a procedure.