Hi, this is my first time writing anything, but I’ve benefitted tremendously from reading the insights shared by others in this group! As others have said, your doctor’s approach will probably depend on many factors. I live in Canada. I was diagnosed with ET about a year ago, having had platelets over 450 since early 2022. My platelet numbers, taken every 4 weeks, currently tend to bounce between 800 and 900. Although I am almost 64 (where did the time go?!), I am just on 81 mg aspirin per day. My hematologist will look at HU if my platelets get to 1,000. I understand that this is because I have fortunately had no clots, am in good health (knock wood) and am triple negative (I have none of the 3 major genetic mutation drivers, so don’t have JAK2). Take care, and best wishes in your health and wellness journey. I hope that my comment is helpful, in showing how some of these factors have affected my hematologist’s approach. Greetings from a winter wonderland, with ~50 cm (~18 inches) of snow!