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Can MGUS be cured by CRISPR?

Blood Cancers & Disorders | Last Active: Oct 29 3:44pm | Replies (9)
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@ewcbhc

Thank you, very much for sharing that information with me. It appears that you have the precise information needed for a CRISPR team to remove that mutation.
Some research scientist should get a grant, write a paper, and win a Nobel prize. Where do research scientists live?

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Replies to "Thank you, very much for sharing that information with me. It appears that you have the..."
kayabbott | @kayabbott | Oct 29 3:12pm

CRISPR was easier for sickle cell anemia because it was one mutation on one chromosome. There are a number of different mutations that can influence MGUS turning to MM, so a much harder task. A focus right now is creating proteins that link to myeloma cells and decrease/end replication by encouraging your immune system to go after the nasty cells (a bit like how the Covid mRNA vaccines work). There are a few medicines for that now, but they are expensive, have side effects, and are mostly for later SMM and MM. Here is one article: https://pmc.ncbi.nlm.nih.gov/articles/PMC8584466/

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