Regarding there is not any scientific evidence to support the uses, they are currently in various trial stages, but many are showing efficacy at those stages. At present, if one uses the vitamin as a therapy, it relies on anecdotal reports, early phase trials, or general information regarding the importance of the co-enzyme nicotinamide adenine dinucleotide (NAD). We should see the Phase 3 results in about 15 months from the Norway trials (NoPark Trials). Since the vitamin has GRAS safety rating from the NIH) and since it may slow or stop the progression fo Parkinson's disease, and perhaps give remedial benefits, I wish it would have been available for my parents.