MGUS: Should I be concerned that my eGFR dropped from 77 to 57

I am entering the MguS or Light Chain Myeloma or whatever diagnosis month right around the corner. For the past nine years I have had labs every three months due to impacts of ANCA Vasculitis on my Kidneys

Several times, I'd say four or five the fluctuations put me similar to where you are saying. I had been dehydrated and overtaxed-this most recent low result and not gotten enough rest; and during that time I had a 20 point drop in eGFR, down to 49%. Two days later it had recovered fully and remained so.

Should the low readings go lower or remain to accumulate as a trend over three to five months time, at that time, then I would presume further testing and/or prescribing may be requested. In fact, the indicator for out of range cuts off at 60% estimated Glomeruli Filtration rate.

Thank you! It’s good to hear from others with a similar experience. I am supposed to have the eGFR retested in a few weeks, so hopefully it goes back up like yours did!

@sue85 Welcome to Mayo Clinic Connect. Have you asked the nurse why she didn't feel concerned? That might be an interesting answer!

Typically we look at trends in kidney function, not just a single result. Possible causes of a radically different result could be: dehydration, change/interactions in medications, a recent or current infection you are dealing with. Can you request a repeat test to see what the results are?

As someone with both active multiple myeloma, and end-stage kidney disease [not related to the myeloma!] watching trends is important to me. I hope you are able to get the answers you need. Please let me know if you have any questions?
Ginger

Thank you, Ginger! I am thankful to have found this site, and I appreciate your insight. I am having the test repeated to look at the trend. I just haven’t quite figured out the whole MGUS thing, but maybe I never will. Watching and waiting is difficult!

@sue85 It's always stressful. You're certainly not alone! Watching and waiting is something it seems we are all familiar with.

A great source of information is the International Myeloma Foundation website myeloma.org. They offer a lot of articles that can help you make sense of things. And of course, our great group here will answer questions based on our experiences. We're not medical professionals, and cannot offer medical advice, but we can share what we have been through!
Ginger

I have had eGFRs vary up and down over my 22 year MGUS odyssey. Dehydration pushes creatinine up and the eGFR down. My lowest value was 57 after a 3 day winter road trip to Minnesota when I drank almost no water. I had an extremely painful
Hip that I was on my way to have replaced. I did not want to get out of the car cause it was freezing cold and my hip was excruciating painful.
That said, dehydration affects a lot of lab values including hemoglobin, hematocrit, glucose, etc..
Do a google search and it is appalling how some diagnoses that depend on reasonably hydrated blood can be affected.
By the way, my eGFR fully recovered by the next blood draw!!

First, it's an estimate.
Second my own has been down to stage 2 kidney disease but came back to normal with only 250 mils of extra water per day.
Third, my sister was treated got spongy medullary disease.at age 80. She died last year well past 102.
Do the best you can win what has been dished up to you and try to focus on every good thing you see so you become/ stay positive.

Thank you for the encouragement!

Thanks for your positive responses. I do hope not too much was lost in my typos.
(Im sure my iPhone has a mind of its own.)

Thanks for sharing!