My oncologist called me yesterday and said that I still have MGUS and it won't have progressed to SMM until my current 300 mg/L kappa levels are in the thousands. I was a research scientist, but not medicine, and know that the interplay and interpretation of genetics, bone marrow and blood test results, and the whole mishmash is complicated. Still, it seems like my oncologist is underplaying my results a bit. My bone marrow biopsy plasma cells are at least 15% (normal is ~2-3% and MGUS usually 5-10%). He said my gain of 1q21 only impacts treatment if someone has MM. I think this is currently correct because most clinical trials on limiting progression are for MM and later stage SMM. MGUS and SMM are waiting games, I do wish the research papers were easier to read, but they are written to a specific audience. Would make an interesting rom-com or mystery tho. The FISH was creeping up on the unsuspecting patient, slowly slithering along, and then pouncing...Oh No! The chromosomes quaked in fear...