When I first started I was taking seven days a week. I felt severe sensitivity to the sun, sore swollen gums and some hair loss. I even had some tiny brown spots in my skin which was told by dermatologist that it’s previous sun damage that the medication makes surface. This was all about a month in. The doctor said to give it time for My body to adjust. I was scared $hit. About two months later I was put to five days a week and the side effects lessened. After seven months I was put on 3X a week and been taking that dosage for over a year now with basically no side effects. I was diagnosed at 56 with PV and almost two years in now. I need phlebotomies about every 8 weeks once my hematocrit hit 45 or over. Platelets steady about 500. Good luck!