I don't think that I have ever been tested for CHEK2 mutation. I was tested for BRCA and that was negative and I was tested for Gene TSC2 Tuberous sclerosis complex and the result was called Uncertain Clinical Significance meaning genetic change that may or may not be contributing to cancer risk.
I have a suspicion that I have some kind of a genetic issue. My mom and sister both had lung cancer and my sister had breast cancer and my grandmother had bladder cancer and my uncle had prostate cancer. I have had benign breast, thyroid, uterine, wrist, colon, knee and finger tumors that were removed. Also, I had 2 different kinds of breast cancer and 1 skin cancer surgery. And I have severe osteoarthrits.
I looked it up and the odds of having CHEK2 is 1.6% and the odds of having Low grade adeno squamous carcinoma is less than 1%. Knowing that you both have both genetic factors is interesting to me. I have a follow up appointment with my radiation oncologist and I think I will bring this up to her in a few weeks.
Have either one of you had an issue with benign tumors, cysts or osteoarthritis?
Thanks for the information. I appreciate it.
Katrina123
I don't think that I have ever been tested for CHEK2 mutation. I was tested for BRCA and that was negative and I was tested for Gene TSC2 Tuberous sclerosis complex and the result was called Uncertain Clinical Significance meaning genetic change that may or may not be contributing to cancer risk.
I have a suspicion that I have some kind of a genetic issue. My mom and sister both had lung cancer and my sister had breast cancer and my grandmother had bladder cancer and my uncle had prostate cancer. I have had benign breast, thyroid, uterine, wrist, colon, knee and finger tumors that were removed. Also, I had 2 different kinds of breast cancer and 1 skin cancer surgery. And I have severe osteoarthrits.
I looked it up and the odds of having CHEK2 is 1.6% and the odds of having Low grade adeno squamous carcinoma is less than 1%. Knowing that you both have both genetic factors is interesting to me. I have a follow up appointment with my radiation oncologist and I think I will bring this up to her in a few weeks.
Have either one of you had an issue with benign tumors, cysts or osteoarthritis?
Thanks for the information. I appreciate it.
Katrina123
@katrina123
It is interesting! I didn’t even know that I was tested for the CHEK2 mutation but At my last appointment my oncologist brought it up and explained it to me. Would definitely be worth asking though. You will have to keep us posted!
Yes, recently I have had to get 2 Myxoid cysts removed….from my toes of all places! These cysts are connected to the joint and have joint fluid inside of them. I asked the doc why I’m getting them and he said he’s not sure but usually has to do with arthritis.
I also have Hashimoto’s Thyroiditis which is an autoimmune disease. Anyone else have that?
I have been trying to see what similarities I share with others who have had LGASC since I was diagnosed. Maybe we will get it figure out, Lol!
@katrina123
It is interesting! I didn’t even know that I was tested for the CHEK2 mutation but At my last appointment my oncologist brought it up and explained it to me. Would definitely be worth asking though. You will have to keep us posted!
Yes, recently I have had to get 2 Myxoid cysts removed….from my toes of all places! These cysts are connected to the joint and have joint fluid inside of them. I asked the doc why I’m getting them and he said he’s not sure but usually has to do with arthritis.
I also have Hashimoto’s Thyroiditis which is an autoimmune disease. Anyone else have that?
I have been trying to see what similarities I share with others who have had LGASC since I was diagnosed. Maybe we will get it figure out, Lol!
I had surgery to remove a myxoid cyst from a finger joint. Unfortunately, it has grown back and I haven't done anything about it yet. I don't have Hashimoto's but I was diagnosed when I was in my 20's with Graves disease and a high thyroid. I had a tumor growing around my windpipe so they removed my thyroid gland and of course after that I had low thyroid.
I don't think that I have ever been tested for CHEK2 mutation. I was tested for BRCA and that was negative and I was tested for Gene TSC2 Tuberous sclerosis complex and the result was called Uncertain Clinical Significance meaning genetic change that may or may not be contributing to cancer risk.
I have a suspicion that I have some kind of a genetic issue. My mom and sister both had lung cancer and my sister had breast cancer and my grandmother had bladder cancer and my uncle had prostate cancer. I have had benign breast, thyroid, uterine, wrist, colon, knee and finger tumors that were removed. Also, I had 2 different kinds of breast cancer and 1 skin cancer surgery. And I have severe osteoarthrits.
I looked it up and the odds of having CHEK2 is 1.6% and the odds of having Low grade adeno squamous carcinoma is less than 1%. Knowing that you both have both genetic factors is interesting to me. I have a follow up appointment with my radiation oncologist and I think I will bring this up to her in a few weeks.
Have either one of you had an issue with benign tumors, cysts or osteoarthritis?
Thanks for the information. I appreciate it.
Katrina123
@susan7656
Yes, we have several of similarities! Mine was also labeled as VUS but my Oncologist said that it is likely “Pathogenic.” Not real sure what that means but she said she was going to do some research before my next appointment in December.
@susan7656
Yes, we have several of similarities! Mine was also labeled as VUS but my Oncologist said that it is likely “Pathogenic.” Not real sure what that means but she said she was going to do some research before my next appointment in December.
@susan7656
In May of 2023 I discovered a lump about the size of a walnut in my right breast. It literally just appeared out of no where and I could see it sticking out when I laid down. I had my lumpectomy and the surgeon told my husband that she took out about the size of a lemon but there was also an area next to it that “looked strange” so she took that also. When my pathology finally came back, I had “extensive grade 2 DCIS and also LGASC (which was what “looked strange”).
I ended up having a sentinel node biopsy but no cancer was found to have spread.
I then learned I needed to have a re-excision surgery because my margins weren’t clear. My Oncotype was 32 so I didn’t need Chemo. I did 20 Radiation treatments and now take Tamoxifen daily.
@susan7656
In May of 2023 I discovered a lump about the size of a walnut in my right breast. It literally just appeared out of no where and I could see it sticking out when I laid down. I had my lumpectomy and the surgeon told my husband that she took out about the size of a lemon but there was also an area next to it that “looked strange” so she took that also. When my pathology finally came back, I had “extensive grade 2 DCIS and also LGASC (which was what “looked strange”).
I ended up having a sentinel node biopsy but no cancer was found to have spread.
I then learned I needed to have a re-excision surgery because my margins weren’t clear. My Oncotype was 32 so I didn’t need Chemo. I did 20 Radiation treatments and now take Tamoxifen daily.
Thanks for that summary. ❤️🩹 I’m sorry you’ve been through this.
My LGASC was found on my annual mammogram. I was not able to feel it and didn’t have any symptoms out of the ordinary. I was diagnosed on September 27, 2024. (Very grateful for the eagle-eyed radiologist who recognized the difference on my mammogram.)
Do you mind sharing how old you are? I am 59. (Im only asking to continue to put together our LAGSC puzzle pieces.)
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@katrina123
Do you know if you have the CHEK2 mutation?
mchler73 and susan7656
I don't think that I have ever been tested for CHEK2 mutation. I was tested for BRCA and that was negative and I was tested for Gene TSC2 Tuberous sclerosis complex and the result was called Uncertain Clinical Significance meaning genetic change that may or may not be contributing to cancer risk.
I have a suspicion that I have some kind of a genetic issue. My mom and sister both had lung cancer and my sister had breast cancer and my grandmother had bladder cancer and my uncle had prostate cancer. I have had benign breast, thyroid, uterine, wrist, colon, knee and finger tumors that were removed. Also, I had 2 different kinds of breast cancer and 1 skin cancer surgery. And I have severe osteoarthrits.
I looked it up and the odds of having CHEK2 is 1.6% and the odds of having Low grade adeno squamous carcinoma is less than 1%. Knowing that you both have both genetic factors is interesting to me. I have a follow up appointment with my radiation oncologist and I think I will bring this up to her in a few weeks.
Have either one of you had an issue with benign tumors, cysts or osteoarthritis?
Thanks for the information. I appreciate it.
Katrina123
@katrina123
It is interesting! I didn’t even know that I was tested for the CHEK2 mutation but At my last appointment my oncologist brought it up and explained it to me. Would definitely be worth asking though. You will have to keep us posted!
Yes, recently I have had to get 2 Myxoid cysts removed….from my toes of all places! These cysts are connected to the joint and have joint fluid inside of them. I asked the doc why I’m getting them and he said he’s not sure but usually has to do with arthritis.
I also have Hashimoto’s Thyroiditis which is an autoimmune disease. Anyone else have that?
I have been trying to see what similarities I share with others who have had LGASC since I was diagnosed. Maybe we will get it figure out, Lol!
@susan7656
Prayers and positive vibes for your upcoming surgery! Please let us know how it goes!
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1 ReactionI had surgery to remove a myxoid cyst from a finger joint. Unfortunately, it has grown back and I haven't done anything about it yet. I don't have Hashimoto's but I was diagnosed when I was in my 20's with Graves disease and a high thyroid. I had a tumor growing around my windpipe so they removed my thyroid gland and of course after that I had low thyroid.
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1 Reaction@katrina123 and @mchler73 -
Thanks for the info.
I have had benign ovarian cysts (I don't think those are that unusual), and I've also had colon polyps removed. None had reached the cancer stage.
I do have osteoarthritis, as well as psoriatic arthritis. @mchler73, it's interesting that we both have autoimmune diseases.
(My CHEK2 mutation was also labeled a VUS ... variant of uncertain significance.)
@susan7656
Yes, we have several of similarities! Mine was also labeled as VUS but my Oncologist said that it is likely “Pathogenic.” Not real sure what that means but she said she was going to do some research before my next appointment in December.
Interesting. Please keep me posted! My oncologist said he would like to see if Natera (the gene testing company) provides any more data.
@mchler73 do you mind summarizing again your breast cancer diagnosis/treatments? (Thanks in advance. We’ve had quite the lengthy thread!)
@susan7656
In May of 2023 I discovered a lump about the size of a walnut in my right breast. It literally just appeared out of no where and I could see it sticking out when I laid down. I had my lumpectomy and the surgeon told my husband that she took out about the size of a lemon but there was also an area next to it that “looked strange” so she took that also. When my pathology finally came back, I had “extensive grade 2 DCIS and also LGASC (which was what “looked strange”).
I ended up having a sentinel node biopsy but no cancer was found to have spread.
I then learned I needed to have a re-excision surgery because my margins weren’t clear. My Oncotype was 32 so I didn’t need Chemo. I did 20 Radiation treatments and now take Tamoxifen daily.
How was your LGASC found?
@mchler73 -
Thanks for that summary. ❤️🩹 I’m sorry you’ve been through this.
My LGASC was found on my annual mammogram. I was not able to feel it and didn’t have any symptoms out of the ordinary. I was diagnosed on September 27, 2024. (Very grateful for the eagle-eyed radiologist who recognized the difference on my mammogram.)
Do you mind sharing how old you are? I am 59. (Im only asking to continue to put together our LAGSC puzzle pieces.)