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@arecchie

I take 500 mg. of Hydrea per day. Take it at bedtime with a cracker or some kind of snack so you have food in your body to accompany it. Drink a glass of water with it. VERY IMPORTANT

Get Lactobacillus Acidophilus from Amazon or your local Walmart, or where OTC drugs are found. It's about 9 dollars per bottle of 120. I take it regularly.

IMPORTANT: This is great for when you have ulcerations in the mouth and are struggling to get rid of or ward them off. Take 4 capsules, 3 X PER DAY WITH any kind of MILK. It needs the milk to help it culture properly for this specific purpose.

You will have relief in under 24 hours and continue to take them. It will not interfere with the Hydrea you are taking, but it will at least help you cope with one of the side effects of the drug. Every time my tongue starts tingling, I rush and take 4 with milk and do that 2 more times during that day. Stops them in their tracks.

I take at least 4 capsules per day with milk every day - even with no symptoms.

Good luck.

Best of luck to you.

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Replies to "I take 500 mg. of Hydrea per day. Take it at bedtime with a cracker or..."

Thank you for the tip about mouth sores. My tongue is sore a lot. I did not know it was from the HU. I don’t drink milk so is there another alternative?

@arecchie, welcome. I'm glad that you found something that works for you. I see you are a new member, so I'd like to point you to the Community Guidelines (https://connect.mayoclinic.org/blog/about-connect/tab/community-guidelines/)

Guideline number 1 encourages members to share what works for them, but to refrain from telling other people what they should do. Probiotics come in many different strains, doses and vary in quality. Here's a helpful guide:
- An introduction to probiotics https://www.mayoclinichealthsystem.org/hometown-health/speaking-of-health/an-introduction-to-probiotics
- How to choose a probiotic https://store.mayoclinic.com/education/probiotics-for-digestive-well-being/

As @janetbender points out, one should always check with their doctor before starting supplements and get a recommendation on what may or may not be right for you. And for @et1055, milk may not be an option. All this to say, everyone is different. Tips are welcome. Be sure they are right for you. Experiences and information shared by members on the Mayo Clinic Connect are not a substitute for professional medical advice, diagnosis or treatment. Never disregard professional medical advice or delay in seeking it because of something you have read on the community.

Back to you @arecchie. What do you find is the benefit of taking Hydrea at night? Was a probiotic suggested for you to help control mouth sores?