Orgovyx and zytiga side effects

Posted by larryf954 @larryf954, Oct 19 4:53pm

I’m a 69 year old, who finished IMRT 5 weeks go and I’ve been on these ADT medications for 4 months now. This last week my fatigue has increased significantly. I’m not surprised but I’m disappointed as I was feeling better after 3 weeks of post radiation difficulty. If you had a similar treatment regiment I’d appreciate it if you would share your side effect experience during the 4-6 month time frame. Wondering what I should expect over the next few months. Thanks

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Since you are on Zytiga with Prednisone and if your fatigue is so bad that you are having a hard time getting out of bed then increasing your prednisone can help. There was a doctor in a recent conference that talked about his Gleason 9 prostate cancer and the fact that he increased his prednisone because he was having too much fatigue. I mentioned it to someone I know, and he got his doctor to allow him to increase his and it helped a lot with fatigue. Speak to your doctor about this see if more prednisone will help you
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With ADT (and Zytiga) exercise is the usual solution. Walking two or more miles a day and doing some exercises can offset the fatigue. I’ve done it for years and after almost 8 years of being on ADT I still don’t have the fatigue issue. I usually can’t sleep more than six hours a night, and I’m not tired when I get up.

You should also try to do weightlifting or equivalent exercises. Your muscles will deteriorate a lot on ADT, keeping them tuned up with exercise can help offset that deterioration. Brain fog is another issue you may encounter, It just happens when you’re on the drugs for a while. A recent trial called the Patch trial found if one used estrogen it can replace Lupron or Orgovyx, and does not have all of the deleterious effects. Look up the patch trial and speak to your doctor.

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I agree with you entirely being 17 months into it. It becomes cumulative and beats me down more each month. The first few months on ADT was a piece of cake.

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just a quick side note: if you watch your a1c and glucose levels, Prednisone may increase those levels quite a bit as it did for me.

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I have been exercising 15 minutes or aerobic exercise and an hour of weightlifting, both 5 times a week. This is the same amount of exercise I’ve been doing most of my life. It’s very challenging with brain fog influencing my motivation; the feeling of severe tiredness after I do a weight exercise; and what feels like being out of breathe but it’s just the body saying stop for a minute. I have kept up the routine, fighting my mind and body as I know that by not doing it I will feel even more fatigued. I hope that I can continue as getting to the gym is becoming more of a challenge both physically and mentally.

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@larryf954

I have been exercising 15 minutes or aerobic exercise and an hour of weightlifting, both 5 times a week. This is the same amount of exercise I’ve been doing most of my life. It’s very challenging with brain fog influencing my motivation; the feeling of severe tiredness after I do a weight exercise; and what feels like being out of breathe but it’s just the body saying stop for a minute. I have kept up the routine, fighting my mind and body as I know that by not doing it I will feel even more fatigued. I hope that I can continue as getting to the gym is becoming more of a challenge both physically and mentally.

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Your younger than I. Go for it. I m too tired at 75. I walk a mile 3x a week and lift light weights daily. Can’t build muscle with 4.6 testosterone level. I m becoming a prune.

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@ecurb

Your younger than I. Go for it. I m too tired at 75. I walk a mile 3x a week and lift light weights daily. Can’t build muscle with 4.6 testosterone level. I m becoming a prune.

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I will be 77 in three weeks. I walk a mile twice a day every day. It seems to help a lot with the fatigue. I did physical therapy for 4 months after having my knee replaced. I’ve had noticeable muscle building, even though I’ve been on Lupron for eight years and my testosterone is extremely low. I started going to the gym three times a week and having a personal trainer work with me once a week, I do exercises the whole time and really don’t take breaks for more than a minute or two in the hour I am there. I’ve had noticeable muscle building occurring, I am able to lift more weight, And do exercises with higher weights with my arms and my legs.

You can rebuild your muscles even with low testosterone and in the late 70’s. You just have to be determined to ignore your fatigue, and it seems to reduce with exercise. You should see how much sweat I have when I’m doing these exercises just dripping off my forehead. Low Testosterone sure brings up the sweat when you’re exercising a lot, bring a towel.

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@ecurb

Your younger than I. Go for it. I m too tired at 75. I walk a mile 3x a week and lift light weights daily. Can’t build muscle with 4.6 testosterone level. I m becoming a prune.

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Not sure how much longer I’ll be able to do it, hence the initial question I posed which was should I expect it to worsen. My takeaway from the posts here is it will get more difficult. Thanks.

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@jeffmarc

Since you are on Zytiga with Prednisone and if your fatigue is so bad that you are having a hard time getting out of bed then increasing your prednisone can help. There was a doctor in a recent conference that talked about his Gleason 9 prostate cancer and the fact that he increased his prednisone because he was having too much fatigue. I mentioned it to someone I know, and he got his doctor to allow him to increase his and it helped a lot with fatigue. Speak to your doctor about this see if more prednisone will help you
.
With ADT (and Zytiga) exercise is the usual solution. Walking two or more miles a day and doing some exercises can offset the fatigue. I’ve done it for years and after almost 8 years of being on ADT I still don’t have the fatigue issue. I usually can’t sleep more than six hours a night, and I’m not tired when I get up.

You should also try to do weightlifting or equivalent exercises. Your muscles will deteriorate a lot on ADT, keeping them tuned up with exercise can help offset that deterioration. Brain fog is another issue you may encounter, It just happens when you’re on the drugs for a while. A recent trial called the Patch trial found if one used estrogen it can replace Lupron or Orgovyx, and does not have all of the deleterious effects. Look up the patch trial and speak to your doctor.

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I will ask my Dr about an increase to my prednisone dosage. Thanks

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@jeffmarc

I will be 77 in three weeks. I walk a mile twice a day every day. It seems to help a lot with the fatigue. I did physical therapy for 4 months after having my knee replaced. I’ve had noticeable muscle building, even though I’ve been on Lupron for eight years and my testosterone is extremely low. I started going to the gym three times a week and having a personal trainer work with me once a week, I do exercises the whole time and really don’t take breaks for more than a minute or two in the hour I am there. I’ve had noticeable muscle building occurring, I am able to lift more weight, And do exercises with higher weights with my arms and my legs.

You can rebuild your muscles even with low testosterone and in the late 70’s. You just have to be determined to ignore your fatigue, and it seems to reduce with exercise. You should see how much sweat I have when I’m doing these exercises just dripping off my forehead. Low Testosterone sure brings up the sweat when you’re exercising a lot, bring a towel.

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Low testosterone makes me sweat too even after a 22:07 second mile. Your diet has to have lots of protein in it to build muscle. We are the same Scorpio. sign - I ll be 76 next month. A Scorpio that stings. Your more ambitious than me, I ll admit it. You have more drive. Great effort in my book.

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@jeffmarc

I will be 77 in three weeks. I walk a mile twice a day every day. It seems to help a lot with the fatigue. I did physical therapy for 4 months after having my knee replaced. I’ve had noticeable muscle building, even though I’ve been on Lupron for eight years and my testosterone is extremely low. I started going to the gym three times a week and having a personal trainer work with me once a week, I do exercises the whole time and really don’t take breaks for more than a minute or two in the hour I am there. I’ve had noticeable muscle building occurring, I am able to lift more weight, And do exercises with higher weights with my arms and my legs.

You can rebuild your muscles even with low testosterone and in the late 70’s. You just have to be determined to ignore your fatigue, and it seems to reduce with exercise. You should see how much sweat I have when I’m doing these exercises just dripping off my forehead. Low Testosterone sure brings up the sweat when you’re exercising a lot, bring a towel.

Jump to this post

I need to do what you do more often as I had 95% blockage of the RCA and a stent installed and Eliquis/ Metprolol intake BID.

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