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Low Grade Adenosquamous Carcinoma. Anyone else diagnosed with this?

Breast Cancer | Last Active: 7 hours ago | Replies (50)
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@katrina123

mchler73 and susan7656

I don't think that I have ever been tested for CHEK2 mutation. I was tested for BRCA and that was negative and I was tested for Gene TSC2 Tuberous sclerosis complex and the result was called Uncertain Clinical Significance meaning genetic change that may or may not be contributing to cancer risk.

I have a suspicion that I have some kind of a genetic issue. My mom and sister both had lung cancer and my sister had breast cancer and my grandmother had bladder cancer and my uncle had prostate cancer. I have had benign breast, thyroid, uterine, wrist, colon, knee and finger tumors that were removed. Also, I had 2 different kinds of breast cancer and 1 skin cancer surgery. And I have severe osteoarthrits.

I looked it up and the odds of having CHEK2 is 1.6% and the odds of having Low grade adeno squamous carcinoma is less than 1%. Knowing that you both have both genetic factors is interesting to me. I have a follow up appointment with my radiation oncologist and I think I will bring this up to her in a few weeks.

Have either one of you had an issue with benign tumors, cysts or osteoarthritis?

Thanks for the information. I appreciate it.
Katrina123

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Replies to "mchler73 and susan7656 I don't think that I have ever been tested for CHEK2 mutation. I..."
mchler73 | @mchler73 | Oct 21 7:01am

@katrina123
It is interesting! I didn’t even know that I was tested for the CHEK2 mutation but At my last appointment my oncologist brought it up and explained it to me. Would definitely be worth asking though. You will have to keep us posted!

Yes, recently I have had to get 2 Myxoid cysts removed….from my toes of all places! These cysts are connected to the joint and have joint fluid inside of them. I asked the doc why I’m getting them and he said he’s not sure but usually has to do with arthritis.

I also have Hashimoto’s Thyroiditis which is an autoimmune disease. Anyone else have that?

I have been trying to see what similarities I share with others who have had LGASC since I was diagnosed. Maybe we will get it figure out, Lol!

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susan7656 | @susan7656 | Oct 21 11:13am

@katrina123 and @mchler73 -

Thanks for the info.

I have had benign ovarian cysts (I don't think those are that unusual), and I've also had colon polyps removed. None had reached the cancer stage.

I do have osteoarthritis, as well as psoriatic arthritis. @mchler73, it's interesting that we both have autoimmune diseases.

(My CHEK2 mutation was also labeled a VUS ... variant of uncertain significance.)

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