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@suzieqqqqq

There are clinical studies that have tested this; and I believe 5 -6 is at the upper limit before rebound happens. My endo and I are planning on 4 Prolia shots, followed up immediately with a biphosphonate program for several years. I might suggest this to your Dr and ask what the downside is … good luck!

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Replies to "There are clinical studies that have tested this; and I believe 5 -6 is at the..."

@suzieqqqqq You suggest that the risk of rebound to Prolia starts at 5-6 fractures. I have never seen evidence that there is a known number of Prolia shots before rebounds happen. If you can find sources for this statement please post it. Your comment could be taken by other readers to mean that it is safe to stop Prolia without a follow up med if you've had up to two years of Prolia. I think that would be dangerous.

It is generally acknowledged that the longer the time on Prolia the greater the risk of multiple fractures after stopping. But again I have never seen anything showing that it is safe to have 4 shots and then stop without a follow up med to help stop the bone loss and possible multi fracturing.

Also it depends on what you mean by "rebound". If you stop with just one Prolia shot you rebound in the sense that you lose the bone you gained from that shot (and maybe more). If you have 10 years of Prolia and stop, you lose all the gain you had with those 10 years. That's one part of "rebound". The other part is that some people start having multiple fractures after stopping. Sometimes large numbers of fractures. I've seen as many as 8-12 fractures claimed on the user groups. Starting and stopping Prolia is serious business.